• WHO. Hantavirus. https://www.who.int/news-room/fact-sheets/detail/hantavirus (WHO, 2026).

  • WHO. Hantavirus Cluster Linked to Cruise Ship Travel, Multi-country 2026. https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON599 (WHO, 2026).

  • López, N., Padula, P., Rossi, C., Lázaro, M. E. & Franze-Fernández, M. T. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220, 223–6 (1996).

    Article 
    PubMed 

    Google Scholar
     

  • Martínez, V. P. et al. Super-spreaders and person-to-person transmission of andes virus in Argentina. N. Engl. J. Med. 383, 2230–41 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Vial, P. A. et al. Hantavirus in humans: a review of clinical aspects and management. Lancet Infect. Dis. 23, e371–e82 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Liu, R. et al. Vaccines and therapeutics against hantaviruses. Front. Microbiol. 10, 2989 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Tscherne, A., Guardado-Calvo, P., Clark, J. J., Krause, R. & Krammer, F. Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology. Front. Immunol. 16, 2025 (2025).

    Article 

    Google Scholar
     

  • Song, J. Y. et al. Immunogenicity and safety of a modified three-dose priming and booster schedule for the Hantaan virus vaccine (Hantavax): A multi-center phase III clinical trial in healthy adults. Vaccine 38, 8016–23 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Cho, H. W. & Howard, C. R. Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax). Vaccine 17, 2569–75 (1999).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Brown, K. S., Safronetz, D., Marzi, A., Ebihara, H. & Feldmann, H. Vesicular stomatitis virus-based vaccine protects hamsters against lethal challenge with Andes virus. J. Virol. 85, 12781–91 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Safronetz, D. et al. Adenovirus vectors expressing hantavirus proteins protect hamsters against lethal challenge with andes virus. J. Virol. 83, 7285–95 (2009).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hooper, J. W., Custer, D. M., Smith, J. & Wahl-Jensen, V. Hantaan/Andes virus DNA vaccine elicits a broadly cross-reactive neutralizing antibody response in nonhuman primates. Virology 347, 208–16 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kuzmin, I. V. et al. Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine. Nat. Commun. 15, 6421 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ramos, K. E. et al. Hantavirus Gn(H) nanoparticle immunogen elicits a cross-neutralizing antibody response in Mice. ACS Infect. Dis. 11, 3061–70 (2025).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Paulsen, G. C. et al. Safety and immunogenicity of an Andes virus DNA vaccine by needle-free injection: a randomized, controlled phase 1 study. J. Infect. Dis. 229, 30–8 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jonsson, C. B., Hooper, J. & Mertz, G. Treatment of hantavirus pulmonary syndrome. Antivir. Res 78, 162–9 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Afzal, S. et al. Hantavirus: an overview and advancements in therapeutic approaches for infection. Front. Microbiol. 14, 1233433 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Moreli, M. L., Marques-Silva, A. C., Pimentel, V. A. & da Costa, V. G. Effectiveness of the ribavirin in treatment of hantavirus infections in the Americas and Eurasia: a meta-analysis. Virusdisease 25, 385–9 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mertz, G. J. et al. Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 39, 1307–13 (2004).

    Article 
    CAS 

    Google Scholar
     

  • Shrivastava-Ranjan, P., Rollin, P. E. & Spiropoulou, C. F. Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin. J. Virol. 84, 11227–34 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bird, B. H., Shrivastava-Ranjan, P., Dodd, K. A., Erickson, B. R. & Spiropoulou, C. F. Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome. Antivir. Res 132, 66–9 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Grande, E. et al. Vandetanib in advanced medullary thyroid cancer: review of adverse event management strategies. Adv. Ther. 30, 945–66 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Safronetz, D. et al. Antiviral efficacy of favipiravir against two prominent etiological agents of Hantavirus Pulmonary Syndrome. Antimicrob. Agents Chemother. 57, 4673–80 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garrido, J. L. et al. Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo. Sci. Transl. Med. 10, eaat6420 (2018).

  • Engdahl, T. B. et al. Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection. Cell Rep. 35, 109086 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brocato, R. L. et al. Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source. mBio 15, e0160024 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duehr, J. et al. Neutralizing monoclonal antibodies against the Gn and the Gc of the Andes virus glycoprotein spike complex protect from virus challenge in a preclinical hamster model. mBio 11, 10–1128 (2020).

  • Mittler, E. et al. Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses. Sci. Transl. Med 14, eabl5399 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vial, P. A. et al. A non-randomized multicentre trial of human immune plasma for treatment of hantavirus cardiopulmonary syndrome caused by Andes virus. Antivir. Ther. 20, 377–86 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guardado-Calvo, P. & Rey, F. A. The surface glycoproteins of hantaviruses. Curr. Opin. Virol. 50, 87–94 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     



  • Source link

    Leave a Reply

    Your email address will not be published. Required fields are marked *