Improving Antibiotic Stewardship for UTIs in Ambulatory Settings

Mackenzie Keintz, MD Image credits: UNMC Ambulatory antibiotic stewardship has focused mainly on respiratory infections, overlooking common conditions like urinary tract infections (UTIs), which make up a significant portion of outpatient antibiotic prescriptions. To address this, researchers developed and validated an antibiotic appropriateness metric for UTIs to improve prescribing practices, reduce unnecessary use, and combat […]

In Response to Outbreak, 2-Dose Hepatitis E Vaccines Shows High Efficacy

Andrew Azman, PhD Image credit: Johns Hopkins Bloomberg School of Public Health According to the Centers for Disease Control and Prevention (CDC), hepatitis E (HEV) is more common in many parts of the world where sanitation is poor and people have limited access to clean drinking water.1 It is more rare in the US, but […]

Fungal Infection Diagnosis, Misdiagnoses, and Global Health Initiatives

David W Denning, FRCP FRCPath FMedSci, professor of infectious diseases and global health at the University of Manchester, and a key figure in GAFFI, discussed the ongoing challenges in diagnosing and treating fungal infections. He also highlighted the goals and successes of the “95-95 by 2025” campaign, which seeks to address global care gaps for […]

Novel Compound Demonstrates Activity Against Vancomycin-Resistant Enterococci

Professor Takeshi Murata, Graduate School of Science, Chiba University Image credit: Chiba University Vancomycin-Resistant Enterococcus (VRE) is an opportunistic pathogen thatcan causes severe hospital-acquired bacterial infections like endocarditis and sepsis and has developed resistance to multiple antibiotics.1 Inpatients at risk for VRE infections include those who are immunocompromised; those who have taken vancomycin and other […]

The Top 5 Infectious Disease News Stories Week of January 18-25

Fungal Infections: Invisible Until It’s Too Late Fungal infections impact over 1 billion people globally each year, leading to millions of life-threatening cases and deaths. In response to this under-recognized health threat, the Global Action Fund for Fungal Infections (GAFFI) launched the “95-95 by 2025” initiative, aiming to diagnose and treat 95% of serious fungal […]

Valley Fever Spreads as Conditions Change

George Thompson, MD, professor of infectious disease at UC Davis Medical Center, has been tracking the increase in coccidioidomycosis (Valley fever) and discussing the current trends and contributing factors. “We’ve seen a big increase in the number of cocci cases over the last two to three years. The central valley looks like there may even […]

Opting for Oral Over Intravenous Antibiotic for Acute Skin Infection

Image credit: Pexels, Gustavo Fring Oral dosing of omadacyline or linezolid was found equally efficacious to intravenous administration in treating acute bacterial skin and skin structure infections (ABSSSI) in a post hoc analysis of two trials that compared safety and efficacy of the 2 antibiotics.1 “Oral therapy can reduce the need for hospitalization or the […]

Invisible Until It’s Too Late

In 2015, fungal infections affected over 1 billion people globally each year, leading to an estimated 11.5 million life-threatening infections and more than 1.5 million deaths annually. Despite their significant impact, fungal diseases have historically been under-recognized and underfunded in global health efforts. In response, the Global Action Fund for Fungal Infections (GAFFI) launched a […]