“Golden Hour” to Start Antibiotic in Suspected Sepsis
Image credit: Stephen Andrews, Unsplash Patients with suspected sepsis in the Emergency Department (ED) have twice the rate of survival at 28 days when antibiotics are started within 1 hour, even when symptoms are not severe and the diagnose is uncertain, according to post-hoc analysis of a trialthat evaluated a sepsis treatment “bundle.”1 Although guidelines2 […]
AI as a Tool to Support Clinicians, Not Replace Them
In this final part of our conversation with Sharmeen Roy, PharmD, BCPS, chief strategy and science officer at DoseMe, she discussed AI as a tool designed to assist pharmacists and clinicians in making more informed patient care decisions. According to Roy, AI is designed to consolidate patient information, aiding clinicians in their decision-making process without […]
Contagion Spring 2025 Digital Edition
View our interactive Spring 2025 digital edition. Source link
AASLD/IDSA Develop a New Algorithm for Hepatitis C Point of Care Testing and Treatment
For people who are battling HCV, there are a number of challenges to getting this patient population into the continuum of care, explains Andrew Aronsohn, MD, associate professor of Medicine, University of Chicago Medical Center. “I think what’s really important to think about when caring for people with hep C—both on an individual and a […]
Real-Time Adaptive Dosing in Critical Care and How AI Contributes
The complexities of individualized medication dosing for critically ill patients, particularly those in intensive care units (ICUs), present significant challenges for clinicians. Sharmeen Roy, PharmD, BCPS, chief strategy and science officer at DoseMe, highlights the need for real-time adaptive dosing models that integrate patient data to optimize care. Critically ill patients experience rapid physiological changes, […]
Investigational Oral Biologic Achieves 100% C difficile Clinical Cure in Preliminary Cohort
Today, Lumen Bioscience reported that its investigational oral biologic, LMN-201, achieved a 100% clinical cure rate of C difficile infection (CDI) in the sentinel cohort (Part A) of its RePreve clinical trial. All patients (21/21; 95% confidence interval [CI]: 85%-100%) achieved initial clinical resolution, significantly outperforming (p << 0.001) the 80% initial clinical cure rate […]
Impact on Patient Safety and Hospital Efficiency
The shift toward Bayesian dosing is transforming how hospitals manage antimicrobial therapy, particularly for medications requiring therapeutic drug monitoring (TDM). As clinicians grapple with increasing patient loads and limited resources, precision dosing offers a safer, more efficient approach to optimizing treatment. Sharmeen Roy, PharmD, BCPS, chief strategy and science officer at DoseMe, explains that vancomycin […]
Nirmatrelvir/Ritonavir Reduces Post-Acute Mortality in Immunocompromised COVID-19 Patients
Marc Ka-Chun Chong, PhD Image credits: CCRB A recent study analyzing the impact of nirmatrelvir/ritonavir (Paxlovid) in immunocompromised patients hospitalized with COVID-19 found that the antiviral therapy was associated with a significantly reduced risk of post-acute inpatient death. Conducted using electronic health records from the Hong Kong Hospital Authority and the Hong Kong Department of […]
Measles Outbreak Grows to 5 States
Captured on the 5th day of this illness, this photograph depicted a posterior view of the back of a patient with a case of measles, highlighting the characteristic erythematous rash that had manifested, and spread over this region. Note how the rash appeared to be a raised crop of irregularly shaped coalescing spots. Image credit: […]
Rising Mucormycosis Cases Drive Efforts for Spotlight on Treatment Research
Researchers are advancing the development of a novel immunotherapy for mucormycosis, a rare and often fatal fungal infection primarily affecting immunocompromised individuals. Ashraf S. Ibrahim, PhD, senior investigator at the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, discussed ongoing research efforts to establish the safety and efficacy of this potential treatment. “What we’re […]
