Global Study Reports 98.9% SVR with SOF/VEL in Over 7,000 Hepatitis C Patients
A multinational real-world study of 7,027 patients treated with sofosbuvir/velpatasvir (SOF/VEL) for hepatitis C virus (HCV) infection reported a sustained virologic response (SVR) rate of 98.9%. “We’re really excited to share this data at EASL this year,” said Anu Oshinusi, MD, MPH, vice president of clinical research for hepatitis, respiratory, and emerging viruses at Gilead […]
Greater Incidence of Antimicrobial Resistant Infections in Cancer Outpatients
Image credit: Ivan Samkov, Pexels Outpatients with cancer were found to be at a greater risk of bacterial infections compared to those without it, according to a new study published in The Lancet Oncology. “The rates and corresponding (IRRs) [Incidence Rate Ratios] of AMR pathogens per 1000 isolates was also higher in patients with cancer […]
Colonoscopic Administration of Rebyota Shows Effectiveness for Preventing Recurrent C difficile Infection
A phase 3b clinical trial has demonstrated that fecal microbiota, live-jslm (RBL), delivered via colonoscopy is a safe and effective treatment for preventing recurrent Clostridioides difficile infection (rCDI) in adults. The CDI-SCOPE study, presented at Digestive Disease Week 2025, conducted at 12 US sites, enrolled 41 adults with a history of rCDI who had recently […]
When Will the Measles Outbreak End?
The Johns Hopkins Bloomberg School of Public Health’s Center for Outbreak Response Innovation has a measles outbreak tracker. Much like they did during the COVID-19 pandemic, and were tracking cases of the virus, the institution is tracking measles cases across all states.1 As of today, May 13, there are 1,014 cases of measles across 31 […]
RSV Vaccine Effectiveness and Safety in Older Adults: Real-World Case-Control Study Findings
RSV vaccine Image credits: Unsplash A large case-control study published in JAMA, 787,822 US adults aged 60 and older found that respiratory syncytial virus (RSV) vaccines were 75.1% effectively prevented RSV-associated acute respiratory infections (ARI), including emergency department visits and hospitalizations. The study also identified a small but measurable increase in Guillain-Barré syndrome diagnoses following […]
FDA and CDC Recommend Pause on Chikungunya Vaccine IXCHIQ for Adults 65 and Older
Chikungunya vaccine Image credits: Unsplash The US Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) have jointly recommended a pause in the use of Valneva’s single-dose chikungunya vaccine, IXCHIQ, for individuals aged 65 and older. This precautionary measure follows reports of serious adverse events (SAEs) in elderly individuals with underlying […]
Microbiota-Based Therapy Improves Mental Quality of Life in rCDI Trial
A new analysis from a phase 3 clinical trial presented at this year’s Digestive Disease Week conference in San Diego, California, shows that a live biotherapeutic used to prevent recurrent Clostridioides difficile infection may also improve patients’ mental quality of life, with outcomes correlating to shifts in the gut microbiome and metabolome. Patients who received […]
Vir Biotechnology Announces Results of its Potential Hepatitis B Cure Combination Therapy
Vir Biotechnology, a clinical-stage immunology company, announced results from its MARCH phase 2 trial, which showed the proportion of participants with undetectable hepatitis B surface antigen (HBsAg) at 24 weeks post-end of treatment, was achieved by 17% (3/18) and 21% (3/14) of participants with baseline HBsAg<1,000 IU/mL who were receiving tobevibart and elebsiran without or […]
Ocular Syphilis and Neurosyphilis in a Patient Living With HIV
Ocular syphilis with optic disc neovascularization Final diagnosis Ocular syphilis and concurrent neurosyphilis History of the Present Illness A 50-year-old man with a medical history notable for HIV/AIDS and a history of previously treated neurosyphilis presented with acute on chronic bilateral visual changes. The patient was in his usual state of health until 6 months prior […]
Top 5 Infectious Disease News Stories Week of May 3 to May 10
Study Highlights Airborne Transmission of H5N1 in Ferrets, Raising Pandemic Concerns A study of the H5N1 virus isolated from a Michigan dairy worker showed it can transmit through airborne particles in ferrets and cause moderate illness, raising concerns about its potential to spread among mammals. The worker’s infection is part of a larger multistate outbreak […]
