Shionogi’s Antibiotic for Use in Adults with Certain Gram-negative Bacterial Infections
Sponsored by Shionogi Inc. Disclaimers Real-world evidence is intended to complement data from randomized clinical trials. Observational retrospective analyses are not intended for direct comparison with clinical trials. In vitro activity does not necessarily correlate with clinical efficacy. Introduction At the IDWeek 2024 annual meeting, several posters and an oral presentation highlighted studies that explored […]
Working to Prevent Malaria Through Genomic Research, Education
The Johns Hopkins Malaria Research Institute was founded in 2001, and has a goal of creating a malaria-free world. The institute conducts discovery research around mosquito parasites at the Bloomberg School of Public Health in Baltimore, and field research at the Macha Research Trust in Zambia, as well as sites in sub-Saharan Africa, India, and […]
Next Generational Antivirals Outperform Paxlovid in Preclinical Coronavirus Testing
Investigator Image creits: Unsplash Two experimental antiviral compounds developed by researchers at the University of California, San Francisco, and Gladstone Institutes have shown superior performance to Paxlovid in preclinical testing against both SARS-CoV-2 and MERS. The findings, published in Science Advances, suggest the new compounds may offer broad protection against current and future coronaviruses.1 The […]
Is Renal-Adjusted Ceftazidime/Avibactam in Patients With KPC-Producing Klebsiella Pneumoniae Bloodstream Infection Associated With Increased Mortality?
Image credit: Adobe stock Carbapenem-resistant Enterobacterales (CRE) are gram-negative bacteria resistant to at least 1 carbapenem. Although CRE isolates can pass multiple mechanisms of resistance, a recent cohort of 261 clinical CRE isolates (defined as resistant to meropenem or imipenem) from 2019 to 2021 in the United States found that of isolates that were carbapenemase […]
Second Generation Antifungal Aims to Address Invasive Fungal Disease
Late last year, Scynexis announced it had begun its phase 1 trial for its investigational fungal compound, SCY-247, which a second-generation antifungal compound, from a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids (fungerps).1 “The reality is that there are not too many antifungal agents, or family of compounds, that are really tailored to the […]
Simplified Hepatitis C Protocols Raise Treatment Uptake and Cure Rates
A recent scoping review in Open Forum Infectious Diseases highlights the success of integrating Hepatitis C treatment into syringe services programs, leading to higher treatment initiation and cure rates among people who inject drugs, who often face significant care access barriers. The review examined 13 US-based studies, including randomized trials, cohort studies, and qualitative evaluations, […]
A Legacy of American Goodwill and Influence
When the US President’s Emergency Plan for AIDS Relief (PEPFAR) launched in 2003, few anticipated the profound global impact it would have. President George W. Bush championed a brand of “compassionate conservatism” that resonated with many. However, when applied to PEPFAR, compassionate conservatism faced criticism from both parties particularly for the PEPFAR program’s initial abstinence-only […]
Integrated Hepatitis C Care in Syringe Service Programs Improves Outcomes for People Who Inject Drugs
A newly published scoping review in Open Forum Infectious Diseases shows that integrating hepatitis C virus treatment into syringe services programs significantly improves treatment initiation and cure rates among people who inject drugs. This population has historically faced major barriers to accessing care. The review analyzed 13 studies from across the United States. These included […]
The Impact of the Pandemic on Antimicrobial Resistance
Hannah WolfordImage credit: Linkedin This is part of an ongoing series looking at the impact of the COVID-19 pandemic on American public health. In a recent CDC study published in JAMA Network Open, investigators found antimicrobial resistance in hospitals declined from 2012 to 2019, but rose again during the acute COVID-19 pandemic years (2020-2021).1 This […]
Pfizer-BioNTech Vaccine Cuts Long COVID Risk by Up to 20x in Children
Infected brain, symbol of Long COVID. Image credits: Unsplash A study by researchers at the University of Pennsylvania’s Perelman School of Medicine found that the Pfizer-BioNTech COVID-19 vaccine protects children and adolescents from Long COVID by preventing initial infections. Analyzing nearly 400,000 pediatric records, the study, published in The Lancet eClinicalMedicine, compared vaccinated versus unvaccinated […]
