Often dismissed as a deadly and dreaded disease of the past, syphilis has made a forceful and frightening comeback in the US. In particular, the recent dramatic increase in syphilis among pregnant women is an urgent public health concern. Between 2016 and 2022, according to a report by the Centers for Disease Control and Prevention, the rate of maternal syphilis more than tripled in the US. In addition, this population-level data source revealed that 47 states have reported recent increases in their maternal syphilis rates. This finding underscores the breadth of this unfolding public health crisis. Predictably and worryingly, the rate of increase was steepest among mothers lacking access to prenatal care.



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