Elke Wollants
Image credits: LinkedIn
Researchers have identified measles virus genotype D8 in wastewater samples from Brussels, Belgium, raising concerns about silent transmission in the region. The findings highlight the growing role of wastewater surveillance in tracking viral circulation and informing public health interventions. The study analyzed wastewater from Belgian treatment plants and detected measles virus in samples collected from Brussels North. Genetic sequencing confirmed a match with 15 known regional measles cases, suggesting broader virus circulation beyond reported infections.
According to the studies researcher and lab manager at Clinical & Epidemiological Virology at KU Leuven, Elke Wollants, “Wastewater surveillance offers a non-invasive way to monitor virus circulation within a population, independent of clinical testing. This is especially valuable for diseases like measles, where not all cases are reported.” By combining wastewater surveillance with viral genotyping, scientists can trace the origins of a virus and its transmission pathways. “Last year, it was D8 from Romania; this year, we have B3 from Morocco,” Wollants noted.
The ability to detect outbreaks early enables more targeted public health responses. “Integrating wastewater surveillance into public health strategies allows for early detection of outbreaks, enabling targeted responses such as localized vaccination campaigns to prevent further spread,” Wollants added.
Challenges in Estimating Cases from Wastewater Data
What You Need To Know
Researchers detected measles virus genotype D8 in wastewater samples from Brussels, linking it to 15 known cases and suggesting broader virus circulation.
Wastewater surveillance provides a non-invasive method to monitor virus spread and offers an early warning system for outbreaks.
Early detection through wastewater surveillance enabled faster public health responses, including vaccination campaigns and media outreach, to prevent further spread.
Despite its potential, accurately estimating the number of active measles cases from wastewater remains a challenge. “The main challenge is quantifying the number of infected individuals based on viral concentrations in wastewater. There is limited data on how much measles virus an infected person sheds and through which bodily fluids,” Wollants explained. Factors such as dilution effects and variations in sewer networks can further complicate measurements. Advancements in research, including improved models and better understanding of viral shedding patterns, are needed to refine these estimates.
The detection of measles virus in wastewater provided an early warning before a significant increase in confirmed cases. “This allowed public health authorities to respond more quickly by alerting general practitioners and launching targeted awareness campaigns,” Wollants said. Identifying genotype D8, already circulating in Europe, emphasized the need to boost vaccination efforts among at-risk populations.
As part of the response, additional vaccination campaigns were organized, and awareness initiatives were expanded. “To further raise awareness, our findings were shared on X, and the message was immediately picked up by local newspapers, TV, and radio,” Wollants noted. The media coverage significantly increased public engagement, prompting many people to check their immune status and seek vaccination where needed.
The study on measles virus genotype D8 detected in Brussels wastewater relates to the measles outbreak in Texas by highlighting the potential for undetected transmission. In Belgium, researchers identified D8 in wastewater samples and confirmed a match with 15 known cases, suggesting broader circulation. In Texas, cases reached 58 total, with 13 hospitalizations and four cases in vaccinated individuals.2 Wastewater surveillance detected the virus before major case spikes in Belgium, showing how early warning systems could support targeted interventions in Texas.
Wollants also mentions, “Measles is making a comeback in Europe,” showing that this is a global issue. These findings underscore the role of wastewater surveillance in infectious disease monitoring, offering an approach to preventing outbreaks before they escalate.
