Gene Duplication is Mechanism for Antifungal Resistance in Madurella fahalii-Caused Mycetoma

Models of the proteins produced by Madurella fahalii: CYP51A (A and C) and CYP51A2 (B and D). In each panel, itraconazole and heme are illustrated in a stick representation in the upper and lower parts, respectively. (A) and (B) represent the overall structure of CYP51 proteins. In (C) and (D), the active centers of (A) […]