FDA Requests Additional Trial of Novavax NVX-CoV2601 Vaccine Prior to Approval
Robert Walker, MD (Credit: Novavax) The FDA has requested that Novavax complete an additional clinical trial for its COVID-19 vaccine, NVX-CoV2601, which it is seeking full approval for after it was granted an emergency use authorization in 2022.1 This news comes just days after the company received communication from the FDA asking for a postmarketing […]
Targeting Apicoplast in All Stages of Malaria Parasite May Prevent Infection Across Hosts
A recent breakthrough from the Indiana University School of Medicine offers new hope for fast-acting antimalarial treatments that could target the malaria parasite across multiple life stages. Led by Sabrina Absalon, PhD, assistant professor of pharmacology and toxicology, the research uncovers a key structural feature in the Plasmodium parasite’s apicoplast, an organelle crucial for parasite […]
Persistent Barriers and Emerging Threats in Malaria Control
For World Malaria Day, we spoke with Andrew Lover, PhD, MPH, MS, associate professor of epidemiology at the University of Massachusetts Amherst and deputy director of the CDC-sponsored New England Center of Excellence for Vector-Borne Disease. Reflecting on his fieldwork in countries such as Cambodia, Vietnam, Laos, and Myanmar, Lover described some of the most […]
Communicable disease threats report, 19 – 25 April 2025, week 17
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 19-25 April 2025 and includes updates on respiratory virus epidemiology in the EU/EEA, influenza, avian influenza, poliomyelitis, and chikungunya virus disease. Source link
Decoding Malaria Parasites to Aid in Potential Treatments and Vaccines
Malaria mostly spreads to people through the bites of infected female Anopheles mosquitoes. Blood transfusion and contaminated needles can also transmit malaria.1 There are 5 Plasmodium parasite species that cause malaria in humans and 2 of these species, P falciparum and P vivax, pose the greatest threat. P falciparum is the most prevalent on the African continent. P vivax is the dominant malaria parasite in […]
Targeting PfAnchor Halts Malaria Parasite Growth in One Cycle
Researchers at Indiana University School of Medicine have identified a protein that plays a critical role in the survival of Plasmodium falciparum, the parasite that causes the most lethal form of malaria. The protein, called PfAnchor, is required to divide and inherit the apicoplast, a unique organelle necessary for the parasite’s replication during the blood […]
Cuts to HIV Assistance Could Undo Years of Progress
Since 2015, global foreign aid has provided nearly 40% of HIV-related funding in low- and middle-income countries. With an anticipated 24% reduction in international aid—in addition to the potential discontinuation of the US President’s Emergency Plan for AIDS Relief (PEPFAR)—a modeling study estimates that 4.4 million to 10.8 million additional HIV infections will occur by […]
Alcohol Use Disorder Among Individuals Who Take HIV PrEP
This cohort study analyzes the prevalence of alcohol use disorder (AUD) diagnoses among commercially insured individuals who take preexposure prophylaxis (PrEP) as well as clinical and demographic characteristics associated with AUD. Source link
Unhealthy Alcohol Use and HIV Preexposure Prophylaxis
Substance Use and Addiction Source link
