New antibodies show potential to defeat all SARS-CoV-2 variants
A Stanford-led team has found two antibodies that can work together to defeat all SARS-CoV-2 variants. More research is needed, but the approach could help in the development of treatments to keep pace with evolving viruses. The virus that causes COVID-19 has been very good at mutating to keep infecting people — so good that […]
Invivyd’s Monoclonal Antibody Neutralizes Against Dominant COVID-19 Strain
Invivyd’s Chief Scientific Officer Robert Allen, PhDImage credit: Invivyd Today, Waltham, Mass.-based biopharmaceutical company,Invivyd, announced its monoclonal antibody, pemivibart (Pemgarda), continued to demonstrate neutralizing activity against the dominant strain of COVID-19, LP81. The variant did not generate any meaningful change to the neutralization activity of pemivibart or VYD2311, the company’s next generation COVID-19 monoclonal antibody […]
FDA Pauses BioNTech’s Malaria Vaccine Trial Amid Broader Vaccine Challenges
The FDA has paused BioNTech’s Phase I/IIa trial of its experimental malaria vaccine, BNT165e, due to unspecified concerns, the company confirmed in an SEC filing on Monday. BioNTech is working with the FDA to address the agency’s requests, though specific details have not been disclosed. Both parties are collaborating to determine the next steps for […]
Ivermectin Does Not Reach Primary Endpoint in Burkina Faso Malaria Trial
A large clinical trial in Burkina Faso found that repeated high-dose ivermectin mass drug administration (MDA) did not significantly reduce malaria incidence in children when integrated with seasonal malaria chemoprevention (SMC). The study, published in The Lancet, evaluated ivermectin’s safety and efficacy in killing malaria-carrying mosquitoes that feed on treated individuals. Despite its safety and […]
Global Guideline on Candidiasis, Part II: Treatments
Oliver Cornely Image credits: CECAD Cologne A new global guideline for management of candidiasis includes treatment recommendations for several clinical circumstances including prophylaxis for at-risk patients, and targeting particular sites of infection.1 The guideline was developed by the European Confederation for Medical Mycology (ECMM) in collaboration with the American Society of Microbiology(ASM) and the International […]
Insights from Phase 3 Trial in Burkina Faso on Ivermectin’s Role in Malaria Control
A large clinical trial in Burkina Faso found that repeated high-dose ivermectin mass drug administration (MDA) did not significantly reduce malaria incidence in children when integrated with seasonal malaria chemoprevention (SMC). The study, published in The Lancet, evaluated ivermectin’s safety and efficacy in killing malaria-carrying mosquitoes that feed on treated individuals. While mosquito survival decreased […]
