Twice-Yearly Lenacapavir Could Support HIV Prevention in Vulnerable Populations
Lenacapavir, a twice yearly injection, may be a promising alternative to the current standard of care for HIV prevention, according to the results of a randomized clinical trial published in the New England Journal of Medicine. Source link
HIV stigma can now be more dangerous than the virus—research shows how to address this
Credit: Pixabay/CC0 Public Domain Speaking at the 16th International Aids Conference in 2006, the then UNAids executive director, Peter Piot, remarked: “Since the beginning of the epidemic, stigma, discrimination and gender inequality have been identified as major causes of personal suffering, and as major obstacles to effective responses to HIV.” Now, in the fourth decade […]
Previously unknown protein interactions may lead to better HIV treatments
The A3F and A3G interaction results in partial protection of A3F from HIV-1LAI Vif-mediated degradation. HIV-1LAI (LAI) and LAI SLQ mutant (SLQM) viruses were used to determine the Vif-mediated degradation of A3F and A3G. The SLQM is SLQ→AAA and prevents Vif from interacting with Elongin C. Immunoblotting with anti-HA and anti-V5 was used to detect […]
Doxycycline Postexposure Prophylaxis to Prevent Bacterial Sexually Transmitted Infection
This JAMA Guidelines Synopsis summarizes the 2024 Centers for Disease Control and Prevention guidelines on use of doxycycline postexposure prophylaxis (doxyPEP) for bacterial sexually transmitted infection prevention. Source link
After lockdown, immune system reacts more strongly to viruses and bacteria
Research from Radboud university medical center shows that the lockdowns during the COVID-19 pandemic had a significant impact on people’s immune response to microorganisms. During the lockdown, inflammation level in the body was low, but afterwards, the immune system reacted more intensely to viruses and bacteria. The results are now published in Frontiers of Immunology. […]
Health groups aim to reach 2 mn people with HIV prevention drug
Credit: Pixabay/CC0 Public Domain Several giant US and international groups focused on fighting HIV and AIDS on Tuesday unveiled a plan to swiftly provide affordable access to a possibly “game-changing” HIV prevention drug in lower-income countries. The Global Fund, a partnership set up to battle AIDS, tuberculosis and malaria, said it had joined forces with […]
Study assesses virulence of Cryptococcus strains, laying groundwork for improved treatment
Ultimately, the goal is to find ways to stop deadly disease caused by Cryptococcus neoformans from developing in humans and animals. But until that time, finding new and better ways to treat already existent disease and its symptoms is a high priority. The laboratory of Kirsten Nielsen in the Center for One Health Research has […]
New guidelines unveil advanced strategies for HIV treatment and prevention
Credit: Pixabay/CC0 Public Domain On the occasion of World AIDS Day on 1 December 2024, the International Antiviral (formerly AIDS) Society-U.S. (IAS-U.S.) has published new international guidelines for the treatment and prevention of HIV. The updated recommendations were developed by a panel of volunteer medical experts, including Prof Clara Lehmann of the University Hospital Cologne […]
Analysis reveals an additional mechanism behind statin therapy’s heart-related benefits in people with HIV
Investigators who previously found that a daily statin pill helps prevent heart attacks and strokes in people with HIV have now discovered a potential mechanism that may help to stabilize plaques and prevent their rupture in blood vessels. The research led by a team from Mass General Brigham is published in JAMA Cardiology. “Individuals with […]
New mechanism found in statin therapy’s heart benefits for HIV
Credit: CC0 Public Domain Investigators who previously found that a daily statin pill helps prevent heart attacks and strokes in people with HIV have now discovered a potential mechanism that may help to stabilize plaques and prevent their rupture in blood vessels. The research led by a team from Mass General Brigham is published in […]
