Investigational E coli Vaccine Does Not ‘Demonstrate Sufficient Efficacy’ in Phase 3 Study
Image credit: Karolina Grabowska, Pexels An independent data monitoring committee (IDMC) determined that the Sanofi and Johnson & Johnson’s vaccine candidate for extraintestinal pathogenic E coli was not sufficiently effective at preventing invasive E coli disease (IED) compared to placebo. No safety signals related to the vaccine candidate were identified.1 “We are disappointed to see that the vaccine was […]
Global Spread of the LP.8.1 SARS-CoV-2 Variant
Kei Sato, PhD Image credits: Loop The LP.8.1 variant of SARS-CoV-2, a descendant of the JN.1 lineage, has been spreading rapidly across the globe, exhibiting notable mutations in its spike protein. As of December 2024, the variant’s relative effective reproduction number (Re) is slightly higher than that of XEC, although transmission dynamics vary between countries […]
Could Inoculum Effect in Staph Endocarditis Affect Choice of Antibiotic?
Produced by the National Institute of Allergy and Infectious Diseases (NIAID), under a magnification of 20,000X, this digitally colorized, scanning electron microscopic (SEM) image, depicts a number of mustard-colored, spheroid shaped, Staphylococcus aureus bacteria, that were in the process of attempting to escape their destruction by blue-colored, human white blood cells (WBCs). Image credit: Frank […]
Insects May Aid Spread of Fluconazole-Resistant Candida auris
Carlien Pohl-Albertyn, PhD Image credits: University of the Free State A study on the South African brown locust (Locustana pardalina) suggests that insects may play a role in the spread of the pathogenic yeast Candida auris (C auris). The researchers isolated three strains of C auris from the locusts, one of which showed resistance to […]
Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment for Early Syphilis
This secondary analysis of a randomized clinical trial assesses the incidence of Jarisch-Herxheimer reaction among adults with early syphilis treated with benzathine penicillin G and the factors associated with Jarisch-Herxheimer reaction and benzathine penicillin G treatment response outcomes. Source link
