Looking at the Slow Adoption of AUC-Based Monitoring for Vancomycin
The development of the AUC-based vancomycin monitoring guidelines published in 2020 by the Infectious Diseases Society of America provided an updated foundation for clinicians and institutions to begin to utilize it, but there is a lot of nuance that needs to be considered when utilizing it. Implementation of AUC-based vancomycin monitoring nationwide is moving in […]
Targeting C difficile with Oxygen-Based Therapy
LPOXY Therapeutics, Inc has acquired key assets from Xeno Biosciences Inc to advance its therapy, SIDIPREV, aimed at preventing Clostridioides difficile (C difficile) infections in hospitalized patients. The acquisition includes regulatory filings, FDA correspondence, CMC data, intellectual property, and Phase I and Ib clinical trial data confirming the safety of the active pharmaceutical ingredient. This […]
Wrong place, wrong time: Why Zika virus hijacks a protein needed for brain growth
The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head. A new study published Jan. 13 in mBio shows that the Zika virus hijacks a host protein called ANKLE2, which happens to be important for brain development, to assist its own reproduction. Because […]
Another Case of Shorter Is Better?
The optimal duration of antibiotic therapy for Streptococcus pneumoniae bacteremia remains a topic of debate in clinical practice. The mortality rate of bacteremia associated with a pneumococcal infection ranges from 6% to 20%.1 Balancing effective treatment with the need to minimize antibiotic exposure is critical, as prolonged courses can contribute to increased risk of Clostridioides […]
COVID-19 Infection Does Not Impact Symptom Severity or Disability Trajectory in Multiple Sclerosis
This article was originally published on our sister site, NeurologyLive. Using a controlled interrupted time series (ITS), a quasiexperimental study design, researchers found that COVID-19 infection was not associated with immediate changes in symptom severity or disability in patients with multiple sclerosis (MS), nor did it change the trajectories of these outcomes over a median […]
Recent Incarceration and HIV Risk Among Women Who Use Heroin
This cross-sectional study examines associations between incarceration and adverse HIV-related and drug use-related outcomes among women who used heroin in Tanzania. Source link
